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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2011 Apr 21;96(2):199–206. doi: 10.1016/j.nlm.2011.04.011

Figure 3.

Figure 3

Chronic MMP inhibition prevents escalated responding for ethanol. Mean (+S.E.M) ethanol consumption during baseline and post-vapor self-administration sessions for animals that had chronic intracerebroventricular FN-439 (n = 7) or artificial cerebrospinal fluid (aCSF, n= 5) treatment via osmotic minipumps during the one month of intermittent vapor exposure and subsequent post-vapor testing. A significant Drug Treatment × Session interaction was found (*= p≤0.05) indicating that the escalation of ethanol self-administration differed over the sessions depending on whether the animals were aCSF-treated or had received FN-439. PVI = initial post-vapor sessions and PVE = escalated post-vapor session.