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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2011 Apr 21;96(2):199–206. doi: 10.1016/j.nlm.2011.04.011

Figure 4.

Figure 4

Acute MMP inhibition, restricted to post-dependence induction acute withdrawal test days, prevents escalated responding for ethanol. Mean (+S.E.M) ethanol consumption during baseline and post-vapor sessions for animals receiving acute intracerebroventricular FN-439 (n = 6) or artificial cerebrospinal fluid (n = 5) infusions following one-month of intermittent vapor exposure. A significant Drug Treatment × Session interaction was found (*= p≤0.05) indicating that acute exposure to FN-439 attenuated the negative reinforcement learning associated with the development of the dependence-like phenotype of excessive ethanol self-administration. PVI = initial post-vapor sessions and PVE = escalated post-vapor session.