Figure 1.

A diagram showing microenvironment-specific responses to front-line chemotherapy. (Left) Systemic chemotherapy can effectively clear the majority of lymphoid tumor cells. (Right) However, genotoxic damage can also engage organ and cell-type specific stress responses. Paracrine pro-survival signaling in select tumor microenvironments can counter the efficacy of anti-cancer agents, leading to the persistence of minimal residual disease.