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The effect of estrogen on cardiac CXCR4 expression following acute I/R. A. Depletion of endogenous estrogen by OVX decreased CXCR4 protein levels in female hearts. B. E2 supplementation did not restore myocardial CXCR4 expression in OVX F hearts. C. Chronic treatment with E2 did not affect male hearts expressing CXCR4 following I/R. Results are mean ± SEM, n=4–5/group, *p<0.05 vs. Female.
