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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biochem Pharmacol. 2011 Jun 13;82(5):514–523. doi: 10.1016/j.bcp.2011.06.011

Figure 1.

Figure 1

CreTek-mediated excision of the ahr floxed allele (ahrfx/fx). (A) Excision by CreTek was determined by genotyping for both the unexcised (140 bp) and excised (180 bp) alleles of ahrfx/fx in genomic DNA isolated from liver, kidney, heart, aorta and mesenteric arterioles obtained from ahrfx/fxCre− (ECahr+/+) and ahrfx/fxCre+ (ECahr−/−) mice. (B) Representative sections of aorta from ECahr−/− and ECahr+/+ mice stained with primary AHR antibody. Positive horseradish peroxidase activity (arrows) can be seen in the endothelium of ECahr+/+, but absent in the ECahr−/− mice.