Table 1.
Demographic data of the studied neonates and pharmacokinetic parameters of first- and second-generation cephalosporins. Figures are the mean±SD.
| Cefazolin – First-generation cephalosporins | ||||||||||
| Gestational age (wk) | Postnatal age (days) | Body weight (g) | No. of cases | Daily dose(mg/kg) | Cl(ml/min/kg) | Vd(L/kg) | t1/2(h) | Peak conc.(µg/ml) | Trough conc. (µg/ml) | Reference |
| 35±3 | 9.4±7.4 | 2,326±943 | 11 | 30 | 0.80 | 0.28±0.05 | na | na | na | 10 |
| Cefoxitin and cefuroxime – Second-generation cephalosporins | |||||||||||
| Drug | Gestationalage (wk) | Postnatal age (days) | Body weight (g) | No. of cases | Daily dose(mg/kg) | Cl(ml/min/kg) | Vd(L/kg) | t1/2(h) | Peak conc.(µg/ml) | Trough conc. (µg/ml) | Reference |
| Cefoxitin | 36±4 | <2 months | 2,404± 599 | 15 | 30×3 | 4.5 | 0.50±0.21 | 1.43±0.53 | 69.8±31.9 | na | 11 |
| Cefuroxime | na | <3 weeks | <1,000 >4,000 | 104 | 10×3 | na | na | 4.6±0.7a | 24.2±8.2 b | 6.4±5.6 b | 12 |
na = not available.
a
Data obtained in 10 neonates.
b
Data obtained in 5 neonates.