Table 4.
Cephalosporin concentration in the cerebrospinal fluid (CSF) and serum in neonates. Figures are the mean±SD, unless otherwise stated.
| Drug | Daily dose (mg/kg) | Drug concentration in CSF (µg/ml) | Drug concentration in serum (µg/ml) | % CSF-to-serum ratio | Reference |
| Cefotaxime* | 50×2 | 18.2±7.4 | 38.6±10.3 | 45±12 | 13 |
| Ceftazidime *a | 50 | 4.7±2.5 | 145±30.4 | 3.5±1.8 | 22 |
| Ceftriaxone* | 75 | 6.5 b | 295±64 | 2.2 b | 29 |
| Ceftriaxone* | 50 | 5.4 b | 230±64 | 2.3 b | |
| Cefoperazone * | 50 | 5.3±3.6 | 89±58 | 10.9±9.6 c | 34 |
| Cefepime * | 50×2 | 4.7±5.3 | 32.7±23.1 | 25.8±29.8 | 43 |
*Infants with meningitis.
a
The infants' ages ranged from 12 to 540 days.
b
Mean; SD was not available. Plasma.
c
The CSF-to-serum ratio ranged from 1.4 to 31.7%.