TABLE 4. Gene Ontology Analysis Performed using PANTHER.

Biological process	P value,a low dose	P value,a high dose
Time: 4 h
mRNA transcription	4.9 × 10−4	NSb
mRNA transcriptional regulation	6.1 × 10−3	NS
Cell cycle	NS	7.8 × 10−9
Cell cycle control	NS	1.6 × 10−2
Cell proliferation and differentiation	NS	1.1 × 10−6
Cell structure and motility	NS	1.5 × 10−2
Chromosome segregation	NS	2.7 × 10−2
Mitosis	NS	1.7 × 10−2
Nucleoside, nucleotide and nucleic acid metabolism	4.6 × 10−2	NS
Other receptor mediated signaling pathways	NS	5.9 × 10−3
Oncogenesis	NS	1.4 × 10−2
Time: 16 h
Cell cycle	2.2 × 10−3	1.9 × 10−2
Cell proliferation and differentiation	2.9 × 10−3	2.3 × 10−2
Chromosome segregation	NS	2.5 × 10−2
Blood circulation and gas exchange	3.5 × 10−2	NS
Time: 24 h
Signal transduction	NS	8.2 × 10−19
Cell surface receptor mediated transduction	NS	1.9 × 10−12
Developmental processes	NS	2.5 × 10−11
Transport	NS	6.8 × 10−9
Cell adhesion	NS	2.6 × 10−3
Immunity and defense	NS	1.6 × 10−2
G-protein mediated signaling	NS	3.9 × 10−7
Neuronal activity	NS	1.9 × 10−6
Cell communication	NS	5.0 × 10−5
Receptor protein tyrosine kinase signaling pathway	NS	1.4 × 10−4
Ion transport	NS	3.2 × 10−5
Cation transport	NS	3.6 × 10−4
Ectoderm development	NS	1.4 × 10−2
Blood circulation and gas exchange	NS	2.3 × 10−2
Cell structure and motility	NS	4.9 × 10−2
Cell adhesion-mediated signaling	NS	2.9 × 10−2
Intracellular signaling cascade	NS	4.1 × 10−2

^aBonferroni corrected.

^bNot statistically significant (P > 0.05).