Table 2.

Multivariable-adjusted negative binomial regression showing the association of each parameter with the relative rate of vascular access thrombosis stratified by baseline access type

Parameter	Fistulas			Grafts
	RR	95% CI	P	RR	95% CI	P
Quartile of intradialytic hypotensiona
Q1	1.00	Reference	–	1.00	Reference	–
Q2	1.06	0.48 to 2.33	0.88	1.28	0.95 to 1.73	0.11
Q3	1.41	0.96 to 2.08	0.08	1.02	0.87 to 1.18	0.82
Q4	2.02	1.22 to 3.35	0.0063	1.11	0.92 to 1.34	0.27
Age (per 10-year increase)	0.85	0.73 to 0.99	0.032	0.99	0.92 to 1.06	0.71
Female gender (versus male)	0.74	0.49 to 1.12	0.15	0.93	0.77 to 1.12	0.43
Black race (versus nonblack)	1.29	0.82 to 2.03	0.27	1.17	0.96 to 1.44	0.12
Current smoker (versus no)	1.07	0.65 to 1.74	0.80	1.03	0.78 to 1.35	0.86
Past medical history (versus none)
diabetes mellitus	0.98	0.61 to 1.56	0.93	1.13	0.94 to 1.35	0.20
ischemic heart disease	0.75	0.49 to 1.14	0.18	0.92	0.76 to 1.11	0.37
congestive heart failure	1.22	0.82 to 1.82	0.32	0.92	0.75 to 1.12	0.40
peripheral vascular disease	1.51	0.93 to 2.46	0.094	1.14	0.93 to 1.39	0.20
Hospitalized during the assessment period (versus no)	1.26	0.91 to 1.75	0.17	1.12	0.98 to 1.29	0.61
Predialysis SBP (per 1-SD increase)	0.92	0.74 to 1.15	0.45	0.88	0.80 to 0.97	0.0099
Serum albumin (per 0.1-g/dl increase)	0.92	0.87 to 0.97	0.0037	0.96	0.93 to 0.98	0.0014
Hematocrit (per 1% increase)	0.98	0.98 to 1.03	0.48	1.00	0.98 to 1.01	0.51
Randomization group
high versus conventional dose	0.96	0.66 to 1.39	0.83	1.09	0.91 to 1.30	0.36
high versus low flux	1.45	1.01 to 2.10	0.046	1.03	0.86 to 1.22	0.78

Analyses adjusted for all variables listed in the table, as well as clinical center. RR, relative rate.

^aGlobal P value for fistulas = 0.069; grafts = 0.41.