Table 2.

Novel sequence variants found in DDD patients

Gene	Variant	Patients	ConSeq	PolyPhen	SIFT	Align GVGD
C3	c0.3607 A>G p.K1203R	1	1	Benign	Affects protein function	Least likely to interfere with function
C3aR1	c0.250 C>T p.L84F	2	4	Possibly damaging	Tolerated	Least likely to interfere with function
CR1	c0.3664 G>T p.V1222L	1	2	Benign	Tolerated	Least likely to interfere with function
ADAM19	c0.1522 G>A p.G507S	1	1	Benign	Tolerated	Most likely to interfere with function