Table 3.

Risk and protective alleles for developing DDD

Gene	Variant	DDD		Controls		Chi-squared P-valuea	Cochran Armitage P-valuea	OR	95% CI
		Minor Allele	Allele Frequency	Minor Alleles	Allele Frequency
CFHR5	−20 T>C	6	0.045	37	0.11	0.020	0.020	0.38	0.16 to 0.92
CFH	Y402H	64	0.48	121	0.37	0.019	0.029	1.63	1.08 to 2.45
C3	R102G	43	0.36	68	0.21	0.0065	0.0091	1.86	1.19 to 2.92
C3	P314L	44	0.33	65	0.20	0.0018	0.0021	2.04	1.30 to 3.20
ADAM19	S284G	58	0.44	82	0.25	5.49E-05	0.00012	1.61	1.04 to 2.51
C4A	Deletion	24	0.18	19	0.06	3.29E-05	1.17E-05	1.88	1.00 to 3.51

^aSignificant P-values: P < 0.05 (uncorrected); P < 0.021 (FDR); P < 0.004 (Bonferroni); DDD, n = 66; controls, n = 165.