Table 4.
Haplotype analysis of CFH SNPs using SNPStats
| Haplotype | −331 T>C | V62I (G>A) | Y402H (T>C) | Q673 (A>G) | Control Frequency | DDD Frequency | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| 1 | C | G | C | A | 0.3218 | 0.4048 | 1.00 | — |
| 2 | C | A | T | A | 0.2420 | 0.1743 | 0.58 (0.33 to 1.00) | 0.05 |
| 3 | T | G | T | G | 0.1050 | 0.1084 | — | NS |
| 4 | C | G | T | A | 0.1193 | 0.1050 | — | NS |
| 5 | T | G | C | A | 0.0159 | 0.0180 | — | NS |
| 6 | C | G | T | G | 0.0065 | 0.0246 | — | NS |
The reference haplotype, which is the most common haplotype in both groups, has OR = 1; the protective haplotype is in bold type. P-values < 0.05 are significant.