Table 6.
ORs of main effects and variant combinations between CFH and C3
| Risk Alleles | DDD Frequency | Control Frequency | OR | 95% CI | P-value | |
|---|---|---|---|---|---|---|
| Main effects | ||||||
| CFH Y402H | H | 47 (0.71) | 93 (0.56) | 1.92 | 1.04 to 3.54 | 0.034 |
| CFH V62I | V | 23 (0.35) | 73 (0.44) | 0.67 | 0.37 to 1.22 | 0.19 |
| C3 R102G | G | 37 (0.56) | 57 (0.36) | 2.42 | 1.35 to 4.33 | 0.0028 |
| C3 P314L | L | 37 (0.56) | 58 (0.35) | 2.35 | 1.32 to 4.21 | 0.0037 |
| Two-variant combinations | ||||||
| CFH Y402H × CFH V62I | H × V | 32 (0.49) | 56 (0.34) | 1.83 | 1.02 to 3.27 | 0.039 |
| CFH Y402H × C3 R102G | H × G | 10 (0.15) | 14 (0.08) | 2.61 | 1.30 to 5.24 | 0.0077 |
| CFH Y402H × C3 P314L | H × L | 12 (0.18) | 12 (0.07) | 3.58 | 1.72 to 7.45 | 8.00E-04 |
| CFH V62I × C3 R102G | V × G | 17 (0.27) | 27 (0.16) | 1.63 | 0.95 to 2.79 | 0.075 |
| CFH V62I × C3 P314L | V × L | 21 (0.32) | 24 (0.15) | 2.47 | 1.43 to 4.27 | 0.0014 |
| C3 R102G × C3 P314L | G × L | 18 (0.27) | 29 (0.18) | 1.87 | 1.14 to 3.07 | 0.014 |
| Three-variant combinations | ||||||
| CFH Y402H × CFH V62I × C3 R102G | H × V × G | 10 (0.15) | 14 (0.09) | 2.74 | 1.26 to 5.94 | 0.011 |
| CFH Y402H × CFH V62I × C3 P314L | H × V × L | 12 (0.18) | 12 (0.07) | 4.51 | 2.01 to 10.13 | 3.00E-04 |
| CFH Y402H × C3 R102G × C3 P314L | H × G × L | 7 (0.11) | 10 (0.06) | 2.49 | 1.05 to 5.91 | 0.04 |
| CFH V62I × C3 R102G × C3 P314L | V × G × L | 16 (0.24) | 22 (0.13) | 2.06 | 1.09 to 3.89 | 0.026 |
P < 0.05 are significant; DDD, n = 66; controls, n = 165.