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. 2011 Jul 11;121(8):3269–3276. doi: 10.1172/JCI44371

Figure 7. PKD inhibition enhances I/R injury and reverses cardioprotection in the CA-RhoA heart.

Figure 7

WT, tTA, and CA-RhoA hearts were perfused with PKD inhibitor CID755673 (50 μM) or DMSO for 30 minutes before I/R. (A) LDH release to the coronary effluent following 45-minute reperfusion. *P < 0.005 versus DMSO (n = 5–9). (B) Representative TTC-stained ventricular sections (top); quantitative analysis of infarct size (bottom). *P < 0.005 versus DMSO (n = 5–9). Sham, WT/tTA mouse hearts subjected to perfusion without ischemia with DMSO or CID755673. Data are shown as mean ± SEM.