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. 2011 Jul 11;121(8):3331–3342. doi: 10.1172/JCI44564

Figure 5. E2 acts directly on islet ERα to suppress lipid synthesis.

Figure 5

(A) Gene expression of Fasn, normalized to Actb, in islets of male ERαlox/lox control and PERα–/– mice treated with 200 μg/d PPT for 2 days (n = 8–24). (B) FAS enzymatic activity in islets of PPT-treated control and PERα–/– mice (n = 6–18). (C) TG content in islets of control and PERα–/– mice treated with 4 μg/d E2 or 200 μg/d PPT for 2 days (n = 9–25). (D) Relative fold increase in TG content in mouse islets after sacrifice at 11 weeks. PERα–/– NC data are duplicated from C (n = 9–36). (E–H) Fasting (E) and fed (F) plasma insulin concentrations, and fasting (G) and fed (H) blood glucose, in control and PERα–/– mice at 9 weeks (n = 10–21). *P < 0.05, **P < 0.01, ***P < 0.001.