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. 2011 Jul 1;121(8):3206–3219. doi: 10.1172/JCI45273

Figure 7. Noggin therapy abrogates MSC-mediated tumorigenesis with an associated decrease in ALDH+ cells.

Figure 7

(A) At euthanasia, average tumor weights of SKOV3 tumors grown with adipose MSCs (control) or CA-MSCs and treated every 48 hours with Noggin or PBS (n = 8 in each group in 2 independent experiments). (B) Western blot demonstrating p-SMAD 1/5 and actin controls in the tumors with and without Noggin therapy or BMP2 treatment. (C) Representative ALDH1 immunohistochemistry and quantification of ALDH1 expression in the indicated control and Noggin-treated tumors. The number of ALDH+ cells were counted in 10 sections from 4 tumors in each treatment group. Average and standard deviations are indicated with P values. Original magnification, ×200. hpf, high-powered field.