Figure 2. Venn diagram showing relationships among some α-synucleinopathies.

Lewy body diseases include PD, PAF, and dementia with Lewy bodies (DLB). The diagram is based on (a) PD being the most prevalent Lewy body disease; (b) PAF being a rare disease; (c) orthostatic hypotension (OH) occurring in a substantial minority of PD patients; (d) DLB overlapping considerably with PD plus dementia (PD+D); (e) MSA being a non–Lewy body form of α-synucleinopathy that involves α-synuclein deposition in glial cytoplasmic inclusions, although (f) a small minority of MSA patients also have Lewy bodies; and (g) some patients initially thought to have PAF proving to have pre-motor PD+OH. Reproduced with permission from Journal of the Neurological Sciences (57).