Figure 3. Effects of desipramine on neuronal uptake and intra-neuronal metabolism of ¹⁸F-DA.

Filled circles show data from untreated healthy controls, and open circles show data from controls pretreated with 125 mg of oral desipramine about 2 hours before ¹⁸F-DA administration. (A) Mean (±SEM) concentrations of interventricular septal myocardial ¹⁸F-DA–derived radioactivity as a function of time after 3-minute constant i.v. infusion of ¹⁸F-DA. (B) Mean concentrations of ¹⁸F-DA–derived radioactivity in the left ventricular chamber. (C) Mean ratios of myocardial to left ventricular chamber radioactivity. (D) Mean arterial plasma concentrations of ¹⁸F-DOPAC.