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FOA + IRN Combination Activity in C26 Cells
| Drug Combination | Ratios | Combination Index* | ||
|---|---|---|---|---|
| EC50 | EC75 | EC90 | ||
| FOA + IRN | 1:10 | 1.1 | 0.99 | 0.89 |
| 1:5 | 1.3 | 1.2 | 1.2 | |
| 1:1 | 1.3 | 1.2 | 1.1 | |
| 5:1 | 0.20 | 0.16 | 0.13 | |
| 10:1 | 0.89 | 0.88 | 0.88 | |
Combination Index is a quantity derived from the median effect equation that describes the degree of a drug interaction. Synergism is indicated for CI < 0.9 (Green), additivity for 0.9 < CI < 1.1 (Yellow), and antagonism for CI > 1.1 (Red).
