Table 2.
Summary of Conditions and Outcomes of FOA + IRN Co-encapsulation into Liposomes at 5:1 Ratio
| Trial | [FOA]o (mM) | IRN D/L Ratio | Load Temp (°C) | Load Temp (min) | [IRN]f (mM) | [FOA]f (mM) | FOA/IRN Ratio |
|---|---|---|---|---|---|---|---|
| i | 7.2 | 0.1/1 | 50 | 60 | 1.21 | 1.74 | 1.4/1.0 |
| 0.2/1 | 2.18 | 0.94 | 1.0/2.3 | ||||
| 0.1/1 | 65 | 1.05 | 0.51 | 1.0/2.1 | |||
| 0.2/1 | 1.73 | 0.21 | 1.0/8.2 | ||||
| ii | 6.13 | 0.1/1 | 50 | 10 | 1.23 | 3.7 | 3.0/1.0 |
| 30 | 1.14 | 3.11 | 2.7/1.0 | ||||
| 60 | 2.29 | 2.05 | 1.1/1.0 | ||||
| iii | 8.69 | 0.1/1 | 40 | 30 | 1.08 | 2.43 | 2.2/1.0 |
| 0.2/1 | 1.93 | 1.81 | 1.0/1.1 | ||||
| 0.1/1 | 45 | 1.15 | 3.61 | 3.1/1.0 | |||
| 0.2/1 | 2.1 | 1.41 | 1.0/1.5 | ||||
| iv | 4.56 | 0.05/1 | 50 | 30 | 0.56 | 2.03 | 3.6/1.0 |
| 0.075/1 | 0.77 | 1.78 | 2.3/1.0 | ||||
| 0.1/1 | 1.07 | 1.53 | 1.5/1.0 | ||||
| 0.15/1 | 1.51 | 1.21 | 1.0/1.2 | ||||
| v | 4.77 | 0.025/1 | 50 | 30 | 0.39 | 2.13 | 5.4/1.0 |
[FOA]o: initial FOA concentration. D/L: drug to lipid ratio. [IRN]f: final IRN concentration. [FOA]f: final FOA concentration.