Skip to main content
. 2011 Jul 28;5:63. doi: 10.3389/fnsys.2011.00063

Figure 3.

Figure 3

Light and electron micrographs of GAT-1 and GAT-3-immunoreactive elements in the rat and monkey globus pallidus. (A,B) Light micrographs of GAT-1 and GAT-3 labeling in the rat striatum (STR) and globus pallidus (GP). (C) GAT-1-immunoreactive axon terminal (Te) and astrocytic process (AS) in the rat GP. Note that the labeled terminal forms a symmetric synapse (arrowhead) with an unlabeled dendrite. (D) GAT-3-positive astrocytic processes in close contact with unlabeled terminals and dendrites in the rat GP. (E) Quantification of the percentage of GAT-1- and GAT-3-labeled elements in the rat GP. Note that GAT-1 is predominantly found in unmyelinated axons, whereas GAT-3 is mainly expressed in glial processes. A total of three rats were used in these studies (see Jin et al., 2009, 2011 for details). (F,G) GAT-1 and GAT-3 immunoreactivity in the monkey putamen (Put) and globus pallidus (external and internal segments, GPe, GPi). (H) GAT-1-immunoreactive unmyelinated axons (AX) and astrocytic processes (AS) in the monkey GPe. Note that the labeled AS is in close contact with an unlabeled terminal (u.TE) that forms an axo-dendritic symmetric synapse [arrowhead; (I,J)] GAT-3-positive astrocytes in the monkey GPe (I) and GPi (J). Note the close association between the immunoreactive AS processes and unlabeled axon terminals forming symmetric synapses [arrowheads in (I)]. (K) Quantitative distribution of GAT-1 and GAT-3 across different neuronal and glial elements in the monkey GPe and GPi (see Galvan et al., 2005, 2010 for more details). Scale bars: (A,B,F,G): 1 mm; (C,D,H,I,J): 1 μm.