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. 2011 Jul 28;5:63. doi: 10.3389/fnsys.2011.00063

Figure 4.

Figure 4

Effects of SKF 89976A and SNAP 5114 on GABA levels in GPe and pallidal discharge rate in monkeys. (A) Dialyzate samples were collected every 10 min. SKF 89976A or SNAP 5114 were administered during sample 4 (horizontal bar). Data area means ± SD from three experiments for each treatment in a single monkey. Difference from ACSF experiments (Mann–Whitney UU test): *P < 0.05. (B1) Example of effect of SKF 89976A on discharge rate of a GPe cell. (B2) Discharge rate of GPe and GPi cells during baseline period and at the point of maximal effect of SKF 89976A. (C1) The discharge rate of this GPe cell is inhibited after administration of the GAT-3 blocker, SNAP 5114. (C2) The discharge rate of GPe and GPi cells during baseline period and at the point of maximal effect of SNAP 5114 injection. In (B1,C1), horizontal bars indicate duration of drug infusions. Dashed lines represent mean discharge rate ± 2 SD. For more details see Galvan et al. (2005).