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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 May 26;31(8):1796–1804. doi: 10.1161/ATVBAHA.111.228924

Figure 4.

Figure 4

Figure 4

Figure 4a: Slit diaphragm proteins Nephrin, Podocin and Extracellular matrix (ECM) proteins TGF-β, Laminin, MyD88, and IRAK-1 phosphorylation in kidney lysates of WT (n=5), TLR2−/− (n=5), WT+STZ (n=14) and TLR2−/−+STZ (n=16) at 6 weeks after diabetes were determined using Western blot. Representative blots with densitometric ratios were shown in the figure. Total IRAK-1 and β-actin were used as internal controls. Values are expressed as protein/β-actin ratio (mean ± SD). *P<0.005 vs WT; †P<0.02 vs WT+STZ.

Figure 4b: TLR2, Nephrin, Podocin, TGF-β, Laminin, MyD88, and IRAK-1 phosphorylation in kidney lysates of WT, TLR2−/−, WT+STZ, and TLR2−/−+STZ (n=11/gr) at 14 weeks after diabetes were measured in kidney tissue lysates using Western blot assay. Representative blots with densitometric ratios were depicted in the figure. Total IRAK-1 and β-actin were used as internal controls. Values are expressed as protein/β-actin ratio (mean ± SD). *P<0.001 vs WT mice. †P<0.05 vs WT+STZ.