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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Immunotherapy. 2011 Apr;3(4):517–537. doi: 10.2217/imt.11.10

Figure 2. Structure of the disulfide trap single-chain trimer.

Figure 2

Representation of a fully folded dtSCT as expressed on the cell surface (A). Note the presence of the Y84C mutation, creating the disulfide trap. SCTs that contain this mutation are more stably expressed on the cell surface. dtSCTs are encoded by a single DNA sequence that, when expressed, produces a peptide–MHC class I complex (B).

β2M: HLA heavy chain; dt: Disulfide trap; SCT: Single-chain trimer.