Table 3.
—Adjusted Association Between the Number of Positive LNs and Survival
Variable | Lung Cancer-Specific Survival Hazard Ratio (95% CI) | Overall Survival Hazard Ratio (95% CI) |
No. of positive LNs | ||
1 | Reference | Reference |
2-3 | 1.16 (1.03-1.30) | 1.13 (1.03-1.26) |
4-8 | 1.53 (1.34-1.75) | 1.46 (1.30-1.64) |
> 8 | 2.25 (1.80-2.81) | 2.17 (1.78-2.65) |
Age, y | 1.03 (1.02-1.04) | 1.03 (1.03-1.04) |
Female gender | 0.79 (0.71-0.88) | 0.78 (0.71-0.85) |
Race/ethnicity | ||
White | Reference | Reference |
Black | 0.91 (0.74-1.12) | 0.96 (0.81-1.15) |
Hispanic | 1.00 (0.77-1.30) | 1.08 (0.86-1.35) |
Other | 0.95 (0.77-1.17) | 0.98 (0.82-1.17) |
Married | 0.90 (0.81-1.00) | 0.87 (0.79-0.95) |
Histology | ||
Adenocarcinoma | Reference | Reference |
Squamous cell carcinoma | 0.66 (0.59-0.75) | 0.76 (0.69-0.84) |
Large cell carcinoma | 1.01 (0.83-1.24) | 1.12 (0.94-1.33) |
Bronchioalveolar carcinoma | 0.91 (0.73-1.13) | 0.97 (0.80-1.18) |
Other | 0.75 (0.59-0.96) | 0.82 (0.67-1.01) |
Tumor status | ||
T1A | Reference | Reference |
T1B | 1.42 (1.12-1.80) | 1.43 (1.17-1.75) |
T2 | 1.29 (1.00-1.65) | 1.30 (1.05-1.61) |
T2A | 1.48 (1.20-1.83) | 1.46 (1.22-1.75) |
T2B | 1.94 (1.54-2.45) | 1.79 (1.47-2.19) |
T3 | 2.21 (1.76-2.77) | 1.97 (1.62-2.40) |
Tumor location | ||
Upper lobe | Reference | Reference |
Middle lobe | 1.24 (0.94-1.64) | 1.21 (0.96-1.54) |
Lower lobe | 1.17 (1.05-1.30) | 1.12 (1.02-1.23) |
Other location | 1.20 (1.01-1.43) | 1.22 (1.05-1.42) |
Type of surgery | ||
Lobectomy | Reference | Reference |
Pneumonectomy | 1.12 (1.00-1.26) | 1.11 (1.01-1.23) |
Postoperative radiation therapy | 1.11 (0.99-1.23) | 1.11 (1.01-1.22) |
See Table 1 legend for expansion of abbreviation.