Table 3. Age-adjusted Relative Risks of Prostate Cancer by AMACR Genotypes and Disease Aggressiveness* in Caucasian Men.
| SNP | Genotype | Less Aggressive | More Aggressive | p-value ˆ |
|---|---|---|---|---|
| rs34680 | ||||
| CC | 1.00 (referent) | 1.00 (referent) | ||
| CT + TT | 1.12 (0.91 – 1.38) | 0.91 (0.70 – 1.19) | 0.15 | |
| rs34688 | ||||
| CC | 1.00 (referent) | 1.00 (referent) | ||
| CT + TT | 1.09 (0.90 – 1.32) | 0.96 (0.75 – 1.22) | 0.32 | |
| rs250412 | ||||
| GG | 1.00 (referent) | 1.00 (referent) | ||
| GA + AA | 1.00 (0.83 – 1.20) | 0.99 (0.79 – 1.24) | 0.92 | |
| rs2278008 | ||||
| TT | 1.00 (referent) | 1.00 (referent) | ||
| TC + CC | 0.85 (0.71 – 1.02) | 1.08 (0.87 – 1.36) | 0.04 | |
| rs2287939 | ||||
| CC | 1.00 (referent) | 1.00 (referent) | ||
| CT + TT | 0.81 (0.68 – 0.97) | 1.06 (0.84 – 1.32) | 0.02 | |
| rs2652130 | ||||
| AA | 1.00 (referent) | 1.00 (referent) | ||
| AC + CC | 1.07 (0.87 – 1.32) | 0.84 (0.63 – 1.10) | 0.10 | |
| rs3195676 | ||||
| AA | 1.00 (referent) | 1.00 (referent) | ||
| AG + GG | 0.90 (0.74 – 1.09) | 0.84 (0.66 – 1.07) | 0.58 | |
| rs6863657 | ||||
| GG | 1.00 (referent) | 1.00 (referent) | ||
| GA + AA | 1.03 (0.82 – 1.29) | 1.12 (0.84 – 1.48) | 0.60 | |
| rs7721230 | ||||
| AA | 1.00 (referent) | 1.00 (referent) | ||
| AG + GG | 0.94 (0.78 – 1.13) | 0.89 (0.71 – 1.12) | 0.69 | |
| rs10941112 | ||||
| AA | 1.00 (referent) | 1.00 (referent) | ||
| AG + GG | 0.92 (0.76 – 1.12) | 0.85 (0.67 – 1.08) | 0.53 |
*
More aggressive cases were defined by a Gleason score of 7(4+3) or greater, or non-localized stage, or PSA > 20 ng/mL at time of diagnosis
ˆ
P-value from a likelihood ratio test for the difference in risk estimates for less versus more aggressive PCa.