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. Author manuscript; available in PMC: 2011 Aug 2.
Published in final edited form as: Brain Behav Immun. 2008 Dec 16;23(5):649–657. doi: 10.1016/j.bbi.2008.12.002

Fig. 9.

Fig. 9

Sex hormones or other mediators released from the testes (male gonads) increase inflammation in the heart following CVB3 infection by increasing proinflammatory GR1−F4/80+ M1 and IL-1β+IL-10+ M2 macrophage populations, and by inhibiting regulatory populations like Tim-3+ M2 macrophages, Tim-3+ T cells, Th2 cells and Treg during acute CVB3-induced myocarditis.