Table 2.
Concentration of DMP in plasma following single I.V. and oral administration of 20 mg kg−1 dose to male Sprague-Dawley rats (μg mL−1)
| Time post-dosing (h) | Plasma concentration (μg mL−1)
|
|
|---|---|---|
| Intravenous | Oral | |
| 0.08 | 138 ± 99.6 | - |
| 0.17 | 93.7 ± 57.7 | ND |
| 0.33 | 36.1 ± 21.9 | 2.05 ± 0.65 |
| 0.5 | 18.9 ± 11.8 | 1.54 ± 0.63 |
| 0.67 | 4.71 ± 3.85 | 0.86 ± 0.55 |
| 1 | 4.05 ± 1.88 | 1.25 ± 0.66 |
| 1.25 | 1.41 ± 1.15 | - |
| 1.5 | 1.14 ± 0.93 | ND |
| 2 | 0.59 ± 0.53 | 0.73 ± 0.63 |
| 4 | ND | ND |
| 8 | ND | - |
ND, non-detected; (−), no sample
Data represents mean ± S.E. for n = 3–5.