Table 3.
Pharmacokinetic parameters of DMP following a single I.V. and oral dose of 20 mg kg−1 to male Sprague-Dawley rats in comparison with results from Timchalk et al. (2007) DEP (dose = 21.6 mg kg−1) and DETP (dose = 23.8 mg kg−1) data obtained from male Sprague-Dawley rats.
| Parameters | Units | Intravenous | DMP (Oral) | DEP (Oral)† | DETP (Oral)† |
|---|---|---|---|---|---|
| α (Distribution) | h−1 | 4.5 ± 0.79 | 4.6 ± 0.79 | 3.5 | 0.17 |
| t 1/2, α | h | 0.17 ± 0.03 | 0.17 ± 0.03 | 0.20 | 4.2 |
| β (Elimination) | h−1 | 0.12 ± 0.01 | 0.12 ± 0.01 | 0.013 | 0.12 |
| t 1/2, β | h | 6.2 ± 0.62 | 6.2 ± 0.62 | 52 | 5.8 |
| ka (Absorption) | h−1 | NA | 0.26 ± 0.08 | 1.3 | 4.2 |
| t 1/2, a | h | NA | 3.6 ± 1.0 | 0.51 | 0.16 |
| Vd/F | mL kg−1 | 6970 ± 905 | 6973 ± 691 | 29 680 | 10 086 |
| Cmax | μg mL−1 | NA | 3.3 ± 0.27 | 0.31 | 2.0 |
| tmax | h | NA | 0.39 ± 0.06 | 1.0 | 0.80 |
NA, not applicable.
Data represents mean ± S.E. for n = 3 – 5.
†
The parameters presented were determined using the plasma concentration time curve data in Timchalk et al. (2007) paper and WinNonlin® software.