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. Author manuscript; available in PMC: 2011 Aug 2.
Published in final edited form as: J Med Chem. 2009 Aug 27;52(16):5228–5240. doi: 10.1021/jm900611t

Scheme 3.

Scheme 3

Reagent and conditions: (a) AlCl3, 1,2-dichloroethane, 35 ºC, 4 h; (b) NH4OAc, NaBH3CN, MeOH, 23 ºC, 24 h; (c) o-toluic acid, EDCI, HOBT, DIPEA, DMF, 23 ºC, 16 h; (d) o-toluic acid, EDCI, HOBT, DIPEA, CH2Cl2, 23 ºC, 16 h.