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. Author manuscript; available in PMC: 2011 Aug 2.
Published in final edited form as: J Med Chem. 2009 Aug 27;52(16):5228–5240. doi: 10.1021/jm900611t

Scheme 5.

Scheme 5

Reagents and conditions: (a) H2, Pd-C, EtOAc/MeOH (1:1), 23 ºC, 15 h; (b) Ac2O, Et3N, CH2Cl2, 23 ºC, 18 h; (c) MeLi, CeCl3, THF, 23 ºC, 2 h; (d) 2-Methyl-5-nitrobenzoic acid, EDCI, HOBT, DIPEA, CH2Cl2, 23 ºC, 16 h; (e) H2, Pd-C, EtOAc/MeOH (1:1), 23 ºC, 15 h.