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. Author manuscript; available in PMC: 2011 Aug 2.
Published in final edited form as: J Med Chem. 2009 Aug 27;52(16):5228–5240. doi: 10.1021/jm900611t

Table 1.

Structure and activity of substituted benzamide derivatives

graphic file with name nihms310703u1.jpg
compound R IC50 (μM)
lead 2-Me 8.7 ± 0.7
5a 3-Me 14.8 ± 5.0
5b 4-Me 29.1 ± 3.8
5c 2-OMe 90 ± 26
5d 3-OMe 13.5 ± 6.8
5e 4-OMe 149 ± 43

(IC50 = enzyme inhibitory activity)