Table 3.
compound | R | R′ | R″ | IC50 (μM) |
---|---|---|---|---|
Lead | 2-Naphthyl | H | 2-Me | 8.7 ± 0.7 |
5h | 1-Naphthyl | H | 2-Me | 2.3 ± 0.1 |
21 | 1-Naphthyl | Me | 2-Me | 22.6 ± 6.9 |
23 | 1-Naphthyl | H | 4-NH2 | 24.8 ± 1.0 |
24 | 1-Naphthyl | H | 2-Me and 5-AcNH | 0.56 ± 0.03 |
25 | 1-Naphthyl | H | 2-Me and 5-NH2 | 2.64 ± 0.04 |
(IC50 = enzyme inhibitory activity)