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. Author manuscript; available in PMC: 2012 Jul 19.
Published in final edited form as: Langmuir. 2011 Jun 16;27(14):8829–8840. doi: 10.1021/la201246m

Table 1.

Biophysical properties of different HBOCs (Hb, Polymerized Hb, RBCs and PEG-LEHs).

Type of Hb Size P50 (mm Hg) N koff, O2 (s −1) kon, CO 106 M−1 s−1 kox, NO 106 M−1 s−1 References
Hb
Human (Hemosol Corp.) 64 kDa 14.50 2.31 42.90 0.200 18.8 47
Human (TFF) 64 kDa 14.07 2.23 40.40 0.214 18.5 47
Bovine (Biopure Corp.) 64 kDa 29.22 2.10 37.80 0.200 19.0 47
Bovine (TFF) 64 kDa 28.58 2.49 36.10 0.216 18.3 47
Human (with PLP) 64 kDa 23.00 1.9 84.00 0.210 87.0 28, 46
Human (TFF) 64 kDa 13.00 2.58 38.71 0.200 27.5 *
Bovine (TFF) 64 kDa 26.02 2.75 38.97 0.198 28.2 *
Polymerized Hb
Bovine (T- and R-state) 16–26 MDa 0.66–41 < 1 22–53 0.18–4.80 17.5–18.9 56
Bovine (Oxyglobin®) 200 kDa 35.10 1.40 60.00 0.150 66.0 28, 46, 57
Human (Hemolink®) 64–600 kDa 47.30 1.00 130 0.120 - 58
RBCs
Human and Rat 8 μm 25.10 2.8 4.4 0.065 0.05 31, 49, 55
Human (GSABC, D.C.) 8 μm 20.00 2.18 16.67 0.130 0.03 *
Bovine (QUAD 5, MT) 8 μm 30.20 2.62 2.01 0.087 0.31 *
PEG-LEHs
Human (with PLP) 279 nm 25–31 2.1 32.00 0.210 8.80 28, 46
Human (TFF) 176 nm 22.87 2.11 21.57 0.212 4.00 *
Bovine (TFF) 174 nm 19.83 1.44 13.13 0.220 2.60 *
*

This study