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. Author manuscript; available in PMC: 2011 Aug 2.
Published in final edited form as: Expert Rev Mol Diagn. 2011 Mar;11(2):197–206. doi: 10.1586/erm.10.117

Figure 1. Proposed path of cystic fibrosis pulmonary exacerbation onset.

Figure 1

Conventionally, CFPE is diagnosed on the basis of an increase in the severity of clinical signs and symptoms. Changes in these markers follow an upregulation of the local inflammatory response. While molecular diagnostic assays based on components of the inflammatory response offer an earlier and more specific indication of the onset of CFPE, the ability to monitor factors associated with triggers of CFPE could allow intervention prior to the infliction of airway damage.

CFPE: Cystic fibrosis pulmonary exacerbation; MW: Molecular weight.