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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: Nature. 2011 Apr 17;472(7344):491–494. doi: 10.1038/nature10075

Figure 2. SR1001 modulates the expression of ROR target genes by decreasing coactivator recruitment.

Figure 2

a, Il17a, Rora, and Rorc mRNA expression in EL4 cells treated with control (C), or mouse RORα/γ siRNA, vehicle (DMSO), or SR1001 (10µM, 24 hours) (n=3). Protein expression of RORα and RORγ is shown. *P<0.05; ***P<0.005. b, ChIP-reCHIP assay in EL4 cells illustrating that SR1001 reduces b, RORα- and c, RORγ-dependent recruitment of SRC-2 and promotes recruitment of NCoR to the Il17 promoter. d, Illustration of the HDX kinetics of peptic peptides derived from the RORγ LBD.. Cyan indicates an increase in protection to exchange; yellow represents a decrease in protection to exchange. Error bars denote sem.