Figure 1.
Dynamics of telomere shortening in patients with myeloproliferative neoplasm (MPN) and in healthy subjects. (A) In healthy controls Spearman’s rank test revealed a significant negative linear correlation between telomere fluorescence, expressed as Molecular Equivalent of Soluble Fluorescence (MESF), and age both in peripheral blood (PB) granulocytes and lymphocytes (P<0.001). In contrast, in MPN patients this relationship was present in PB lymphocytes (P<0.001) but not in granulocytes (P=0.40). (B) Age-corrected telomere length (DeltaTELgran) is significantly shorter in MPN patients (median value −11.14, range −23.99 to 9.78) than in healthy individuals (−0.05, −4.74 to 5.75; Kolmogorov-Smirnov’s test P<0.001).