Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Aug 2;6(8):e22517. doi: 10.1371/journal.pone.0022517

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

PKH67-labeled exosomes were injected in the right footpad of OVA-sensitized mice as in the DTH experiment. Footpads and the popliteal LNs were harvested, cryo-sectioned and examined by immunofluorescence. Similar observations were made with different tumor exosomes and data show the representative figures of MO5 exosomes. (A) 24 h post-injection, exosomes (green) were captured by dermal CD11c+ cells (red) in footpads and transported to the treated-side LN. (B) 48 h post-injection, large numbers of exosome-internalized CD11c+ cells (red, upper left panel) appear in the treated-side LN. Exosomes (or exosome-containing cells) were also physically adjacent to CD3+ T cells (red, lower left panel). Only very few exosomes were observed in the contralateral LN. (C) TUNEL staining for apoptotic cells (red) in both side LNs 48 h post-injection. Magnification: 20×.