Table 5.

 Absolute risks of adverse outcomes over one year by antidepressant class and top 11 most commonly prescribed antidepressant drugs

	Absolute risks over 1 year (%)
	All cause mortality	Attempted suicide/self harm	Myocardial infarction	Stroke/TIA	Falls	Fracture	Upper GI bleed	Epilepsy/seizures	RTA	Adverse drug reaction	Hyponatraemia
Antidepressant class
Not taking antidepressants	7.04	0.25	1.00	2.23	3.46	1.76	0.42	0.21	0.16	0.26	0.29
Tricyclic antidepressants	8.12	0.43	1.09	2.26	4.49	2.18	0.54	0.21	0.13	0.28	0.30
Selective serotonin reuptake inhibitors	10.61	0.55	1.15	2.61	5.67	2.74	0.51	0.38	0.14	0.30	0.44
Other antidepressants	11.43	1.30	1.04	3.04	4.79	2.85	0.57	0.46	0.10	0.25	0.37
Tricyclic antidepressants
Amitriptyline hydrochloride	7.72	0.27	1.11	2.24	4.54	2.14	0.58	0.24	0.13	0.25	0.33
Dosulepin hydrochloride	7.26	0.48	1.07	2.12	4.28	2.15	0.51	0.10	0.08	0.23	0.24
Lofepramine	10.43	0.66	1.18	2.79	4.61	2.56	0.51	0.28	0.18	0.55	0.27
Trazodone hydrochloride	12.44	1.20	1.04	2.45	5.32	1.70	0.75	0.30	0.24	0.27	0.43
Selective serotonin reuptake inhibitors
Citalopram hydrobromide	10.69	0.68	1.11	2.71	6.01	2.83	0.56	0.37	0.16	0.29	0.47
Escitalopram	10.06	0.47	1.32	2.70	5.70	2.26	0.45	0.36	0.15	0.29	0.59
Fluoxetine hydrochloride	11.42	0.53	1.31	2.57	5.60	2.76	0.48	0.31	0.11	0.31	0.49
Paroxetine hydrochloride	8.68	0.29	1.11	2.39	4.97	2.56	0.48	0.42	0.14	0.24	0.30
Sertraline hydrochloride	10.20	0.53	0.89	2.70	5.57	2.80	0.44	0.55	0.14	0.42	0.29
Other antidepressants
Mirtazapine	12.05	1.56	1.11	3.06	4.11	2.56	0.44	0.33	0.07	0.27	0.31
Venlafaxine hydrochloride	11.40	1.17	1.05	3.34	5.74	3.26	0.72	0.61	0.11	0.23	0.44

GI=gastrointestinal; RTA=road traffic accident; TIA=transient ischaemic attack.

*Absolute risks for antidepressant drugs adjusted for confounders listed in table 3.