Table 4.
Identification of variation in Tp1 and Tp2 epitopes
Epitope | Parasite | Nucleotide and amino acid sequencesa) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tp1214–224 | Muguga | GTA | GGG | TAT | CCA | AAG | GTT | AAA | GAA | GAA | ATG | CTA |
V | G | Y | P | K | V | K | E | E | M | L | ||
Kilifi KL1 | GTA | GGG | TAT | CCA | AAG | GTT | AAA | GAA | GAA | ATT | CTA | |
V | G | Y | P | K | V | K | E | E | I | L | ||
Marikebuni | GTA | GGG | TAT | CCA | AAG | GTT | AAA | GAA | GAA | ATT | ATA | |
V | G | Y | P | K | V | K | E | E | I | I | ||
Tp249–59 | Muguga | AAA | TCA | TCA | CAT | GGT | ATG | GGA | AAG | GTA | GGA | AAA |
K | S | S | H | G | M | G | K | V | G | K | ||
Nyairo BR187 | TTA | ACA | TCA | CAT | GGA | ATG | GGA | AAG | ATA | GGT | AGA | |
L | T | S | H | G | M | G | K | I | G | R | ||
Kakuzi 498 | TTA | ACA | TCA | CAT | GGT | ATG | GGA | AGG | ATA | GGG | AGA | |
L | T | S | H | G | M | G | R | I | G | R | ||
Tp298–106 | Muguga | CAA | AGC | CTA | GTG | TGC | GTA | TTA | ATG | AAA | ||
Q | S | L | V | C | V | L | M | K | ||||
Nyairo BR187 | GCA | AGC | ATT | AAG | TGT | GTA | TCA | CAC | CAT | |||
A | S | I | V | C | V | S | H | H | ||||
Kakuzi 498 | GCA | AGT | ATT | AAG | TGT | GTA | GCA | CAA | TAT | |||
A | S | I | K | C | V | A | Q | Y |
Substitutions with respect to Muguga are highlighted in grey.