Table 2.

Clinical signs observed during dosing and withdrawal following pentobarbital and vehicle.

Day	Hours	Vehicle	Pentobarbital constant	Pentobarbital escalation
D2	26	–	↓ Body tone	–
D13	290	–	–	↓ Handling reactivity
				↓ body tone*
				↓ ataxia
D14	314	–	–	↓ Body tone
W15	338	–	–	Straub tail*

*p ≤ 0.05 compared to vehicle.