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. 2011 Apr 5;19(8):1558–1568. doi: 10.1038/mt.2011.29

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Copyright © 2011 The American Society of Gene & Cell Therapy

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Antitumor effect of Ad-ΔB7/IL12/GMCSF in combination with dendritic cell (DCs). (a) Pre-established B16-F10 tumor was injected with phosphate-buffered saline (PBS) (open diamonds), DCs (open squares), Ad-ΔB7/IL12/GMCSF (filled triangles), Ad-ΔB7/IL12/GMCSF plus DCs (filled squares), or Ad-ΔB7/IL12/GMCSF (H; high-dose of Ad) plus DCs (filled diamonds). Tumor growth was monitored every day. (b) Survival percentage of tumor-bearing mice following treatment with Ad-ΔB7/IL12/GMCSF and/or DCs. Tumor size over 3,000 mm³ was regarded as death. Data points represent the mean ± SE. All results in this figure represent results of at least seven mice per group. *P < 0.05. GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin.