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Schematic diagram illustrating mitochondrial macromolecule delivery via a series of membrane fusions using dual function (DF)-MITO-Porter. Complexed particles of cargos are coated with mitochondria-fusogenic lipid envelope (inner) and endosome-fusogenic lipid envelope (outer). Octaarginine (R8) functions as a cell-uptake device in the outer envelope and as a mitochondrial targeting device in the inner envelope.
