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. 2011 May 2;20(7):1172–1181. doi: 10.1002/pro.646

Figure 5.

Figure 5

Specificity of HCPTP variants towards EphA2 tyrosines with linked pathways and functions. The juxtamembrane region is shown as an unstructured loop with three phosphorylated tyrosines (Y575, Y588, and Y594) represented by purple circles. The juxtamembrane tyrosines play a role in activation and inhibition of kinase activity, interact with Vav GEFs, and participate in other SH2 mediated reactions. The rate of dephosphorylation of the juxtamembrane by HCPTP variants is comparable. The kinase domain is shown in orange with the activation loop tyrosine (Y772) marked as a purple circle. Y772 is the preferred site for dephosphorylation by HCPTP-A. The SAM domain of EphA2 (red) has been shown to interact with the SAM domain of Ship2 and regulate EphA2 endocytosis through PI3K dependent Rac1 activation. The SAM domain tyrosine, Y960 is a target for dephosphorylation only by HCPTP-B.