Fig. 1.
Histopathology of the proximal gastric corpus of male INS-GAS mice. (a) Uninfected intact male with moderate corpus gastritis. (b) Uninfected castrated male with mild corpus gastritis. (c) Uninfected E2-treated male with attenuated gastritis. (d) Helicobacter pylori-infected male with marked inflammation and mucosal hyperplasia and dysplasia. (e) H.pylori-infected castrated male with severe gastritis comparable with infected intact males. (f) H.pylori-infected E2-treated male with less severe gastritis than infected intact male INS-GAS.