Table III.

SNP associations with NET in the discovery and replication sets (selected SNPs are those associated with NET risk in the discovery set with adjusted^a P-value under 0.01)

Gene	Variable	Discovery set (n = 261 cases, 319 controls)					Replication set (n = 235 cases, 113 controls)
		Dominant aOR* (95% CI)	Dominant P-value	Additive aOR* (95% CI)	Additive P-value	HWE-P	Dominant aOR* (95% CI)	Dominant P-value	Additive aORa (95% CI)	Additive P-value	HWE-P
TSC2	rs13337626	2.82 (1.89, 4.19)	3.18E-07	2.46 (1.69, 3.57)	2.69E-06	0.50	Failed genotyping
IL1RN	rs380092	1.87 (1.32, 2.65)	0.0004	1.65 (1.27, 2.15)	0.0002	0.61	0.61 (0.38, 0.98)	0.04	0.69 (0.49, 0.97)	0.03b	0.88
CYP1B1	rs162562	1.75 (1.23, 2.48)	0.002	1.51 (1.11, 2.04)	0.008	0.69	1.21 (0.75, 1.95)	0.44	1.20 (0.79, 1.82)	0.41	0.54
BIRC5	rs1508147	1.76 (1.22, 2.53)	0.002	1.37 (1.07, 1.76)	0.014	0.19	0.93 (0.57, 1.50)	0.75	0.92 (0.65, 1.29)	0.61	0.45
AKAP9	rs6964587	0.58 (0.41, 0.83)	0.003	0.70 (0.55, 0.91)	0.006	0.47	1.46 (0.89, 2.37)	0.13	1.27 (0.91, 1.77)	0.17	0.65
IL12A	rs2243123	1.68 (1.18, 2.38)	0.004	1.43 (1.09, 1.89)	0.011	0.40	1.53 (0.97, 2.43)	0.07	1.47 (1.03, 2.12)	0.04	0.62
BCL2	rs7234941	0.58 (0.40, 0.84)	0.004	0.59 (0.42, 0.84)	0.013	0.04	1.21 (0.72, 2.02)	0.48	1.18 (0.74, 1.88)	0.48	0.37
APAF1	rs1007573	0.53 (0.34, 0.82)	0.004	0.60 (0.40, 0.90)	0.012	0.56	0.89 (0.48, 1.64)	0.70	0.99 (0.55, 1.64)	0.85	0.96
BCL2	rs1982673	0.57 (0.38, 0.85)	0.005	0.59 (0.42, 0.84)	0.003	0.50	Failed genotyping
DAD1	rs8005354	1.65 (1.15, 2.35)	0.006	1.31 (1.03, 1.67)	0.028	0.04	1.52 (0.96, 2.41)	0.07	1.43 (1.02, 2.02)	0.04	0.62
APAF1	rs2288713	0.55 (0.36, 0.85)	0.007	0.62 (0.42, 0.92)	0.018	0.60	0.90 (0.49, 1.68)	0.75	0.98 (0.55, 1.75)	0.94	0.29
CYP1B1	rs10916	1.62 (1.13, 2.30)	0.008	1.44 (1.06, 1.95)	0.019	0.70	Failed genotyping
MS4A6A	rs1019670	0.67 (0.47, 0.95)	0.026	0.67 (0.52, 0.87)	0.002	0.72	1.00 (0.62, 1.62)	0.99	0.94 (0.68, 1.31)	0.73	0.47
FRAP1	rs12124983	1.52 (1.07, 2.14)	0.019	1.51 (1.16, 1.97)	0.002	0.10	0.83 (0.53, 1.32)	0.44	0.90 (0.63, 1.27)	0.53	0.67
CASP7	rs4342983	1.80 (1.14, 2.86)	0.013	1.85 (1.19, 2.89)	0.007	0.21	0.95 (0.48, 1.86)	0.87	0.92 (0.49, 1.73)	0.79	0.51
FRAP1	rs1064261	1.42 (1.01, 2.01)	0.05	1.45 (1.11, 1.90)	0.007	0.21	0.84 (0.53, 1.34)	0.46	0.99 (0.71, 1.37)	0.94	0.52
TERT	rs2075786	1.38 (0.97, 1.97)	0.07	1.41 (1.10, 1.80)	0.007	0.73	1.47 (0.93, 2.33)	0.10	1.29 (0.87, 1.74)	0.25	0.68
ADH1C	rs698	1.46 (1.02, 2.08)	0.04	1.38 (1.08, 1.77)	0.01	0.94	1.11 (0.68, 1.79)	0.68	1.14 (0.82, 1.59)	0.45	0.46

CI, confidence interval. SNPs considered to replicate in bold.

^aAdjusted for age, sex and smoking (discovery), adjusted for age and sex (replication).

^bRisk association in discovery and replication are in opposite directions, so not reported as replicating.