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. 2011 Aug 1;208(8):1695–1705. doi: 10.1084/jem.20102657

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© 2011 Anandasabapathy et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Phenotype of Flt3L-responsive CD45^hiCD11c⁺MHC II⁺ cells in the steady-state mouse brain. (A and B) Flow cytometric dot plots of EYFP expression in brain leukocytes (A) and the splenocytes (B) of untreated (top) versus Flt3L-treated (bottom) CD11c-EYFP transgenic mice. Numbers indicate percentage of gated cells. Data are representative of three independent experiments. (C) Flow cytometric dot plots of CD45⁺ mononuclear cells in the brain of untreated (top) versus Flt3L-treated (bottom) nontransgenic C57BL/6 mice. Histograms show MHC II staining on the surface of DCs and microglia (MG) from the indicated gates. Data are representative of more than three independent experiments. (D) Bar graph shows quantification of m/chDCs and microglia 14 d after Flt3L treatment in B6 mice. Bars represent data from two pooled experiments, each with two brains. Error bars represent the mean ± SEM (n = 4; ***, P < 0.0001).