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. 2011 Aug 1;208(8):1571–1577. doi: 10.1084/jem.20110236

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© 2011 Zhao et al.

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Figure 3. — Expression of TNF and IL-10, but not IL-2, by rJ2.2-specific T reg cells. CNS-derived lymphocytes were pooled from rJ2.2-infected Foxp3^gfp mice at 14 d after infection and analyzed for IFN-γ, TNF, IL-10, and IL-2 production after peptide stimulation. Cells were gated on GFP⁻ (T eff) or GFP⁺ (T reg) CD4 T cells. (A and B) A majority of IFN-γ–expressing M133 + S358–specific T reg cells also produced TNF but none expressed IL-2. (C and D) Dual expression of IL-10 and IFN-γ by M133 + S358–specific T reg cells was detected. (A, B, and D) Pooled data from 6–10 pooled brain samples analyzed in three to five independent experiments are shown. Error bars indicate mean ± SEM.