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. 2011 Aug 1;208(8):1579–1584. doi: 10.1084/jem.20101484

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© 2011 Gaspal et al.

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Figure 1. — Deficiency in OX40 and CD30 confers protection from FoxP3-dependent autoimmunity. (A) Kaplan-Meier survival curve for FoxP3^KOdKO^het (n = 30 males), FoxP3^KOOX40^KOCD30^het (n = 8 males), FoxP3^KOOX40^hetCD30^KO (n = 5 males), and FoxP3^KOdKO mice (n > 20 males and n > 30 females). (B) Body weight of WT male littermate controls (FoxP3^hetdKO^het) and male FoxP3^KOdKO^het mice taken at the time of sacrifice, FoxP3^KOdKO male aged 5 wk, and old FoxP3^KOdKO male mice (aged 8 mo) or dKO male mice (aged 8 mo). The horizontal bars show the median. *, P < 0.002. (C) Ear photograph of a 5-wk-old FoxP3^KOdKO^het male with eczema and scurfy skin (top) and a FoxP3^KOdKO male littermate (bottom). Data are representative of at least five separate experiments.