Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Aug 1;208(8):1721–1735. doi: 10.1084/jem.20101920

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Schnoor et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Cortactin deficiency leads to increased vascular permeability in vivo. (A) Cttn^del/del and Cttn^WT/WT mice were injected i.v. with Evans blue and 10 min later intradermally with histamine or PBS alone. Animals were sacrificed after an additional 30 min, and the dye was extracted from skin samples and quantified. Data are presented as means ± SD. n = 12 (WT); n = 11 (KO). ***, P < 0.001. Four independent assays with three to four mice per group were performed. (B) Lung lysates from Cttn^del/del (KO) and Cttn^WT/WT (WT) mice were analyzed by Western blot and probed for the indicated proteins. A representative blot from three independent experiments is shown. (C) Whole mount stainings of cremaster muscles from Cttn^del/del (KO) and Cttn^WT/WT (WT) mice for VE-cadherin and ESAM. Images are representative for three independent preparations each. Bars, 50 µm.